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Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients

Received: 4 January 2022     Accepted: 4 February 2022     Published: 16 February 2022
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Abstract

Monitoring of clinical and laboratory Takayasu's arteritis (TAK) activity was carried out in 40 patients. Most of them were female patients (92.5%), of Kyrgyz nationality (97.5%), of young age (median - 32 years [24; 44]), with a disease duration of 7.5 years (median – (3.5; 12.5)), with the onset of the disease at 24 years (median –(19; 30)), with V anatomical type - (72.5%), which had vascular stage (77.5%), III grade (≥2) of vascular complications (37.5%), severe exacerbation (65%), with pronounced activity (92.5%) according to the EULAR criteria, high laboratory activity (accelerated ESR in 75% and increased hsCRP - in 65.71% of patients). The lesion of the common carotid (85%) and subclavian arteries (85%) prevailed, the renal arteries were the second most frequently (62.5%) affected vessels, with a predominance of bilateral stenosis (96.1%). During the 5.5 year- follow-up course, a statistically significant partial remission (according to the BVAS index) was achieved in only 12.5% of patients, while frequency of mild and severe exacerbations of the disease remained at the same level (p> 0.05). However, according to the EULAR criteria, there was a statistically significant decrease in the disease activity (from 92.5% to 65% cases) and an increase in the frequency of remission (from 2.5% to 27.5% cases), with the exception of episodes of relapses: major (12.5%) and minor ones (45%).

Published in Science Journal of Clinical Medicine (Volume 11, Issue 1)
DOI 10.11648/j.sjcm.20221101.13
Page(s) 14-24
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Takayasu's Arteritis, Disease Activity, Angiography, Doppler Ultrasound, Tomography, Monitoring

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Cite This Article
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    Koilubaeva Gulazyk Malikovna, Bolotbekova Altynai Maratovna, Egorova Olga Nikolaevna, Tarasova Galina Michailovna, Sarybaev Akbai Shogaipovich, et al. (2022). Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients. Science Journal of Clinical Medicine, 11(1), 14-24. https://doi.org/10.11648/j.sjcm.20221101.13

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    Koilubaeva Gulazyk Malikovna; Bolotbekova Altynai Maratovna; Egorova Olga Nikolaevna; Tarasova Galina Michailovna; Sarybaev Akbai Shogaipovich, et al. Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients. Sci. J. Clin. Med. 2022, 11(1), 14-24. doi: 10.11648/j.sjcm.20221101.13

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    AMA Style

    Koilubaeva Gulazyk Malikovna, Bolotbekova Altynai Maratovna, Egorova Olga Nikolaevna, Tarasova Galina Michailovna, Sarybaev Akbai Shogaipovich, et al. Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients. Sci J Clin Med. 2022;11(1):14-24. doi: 10.11648/j.sjcm.20221101.13

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  • @article{10.11648/j.sjcm.20221101.13,
      author = {Koilubaeva Gulazyk Malikovna and Bolotbekova Altynai Maratovna and Egorova Olga Nikolaevna and Tarasova Galina Michailovna and Sarybaev Akbai Shogaipovich and Chukubaev Marat Abdyganovich and Turdukulov Zamir Ergeshevich and Usupbaeva Dinara Abulmeizovna and Turusbekova Aijan Kemelovna},
      title = {Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients},
      journal = {Science Journal of Clinical Medicine},
      volume = {11},
      number = {1},
      pages = {14-24},
      doi = {10.11648/j.sjcm.20221101.13},
      url = {https://doi.org/10.11648/j.sjcm.20221101.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20221101.13},
      abstract = {Monitoring of clinical and laboratory Takayasu's arteritis (TAK) activity was carried out in 40 patients. Most of them were female patients (92.5%), of Kyrgyz nationality (97.5%), of young age (median - 32 years [24; 44]), with a disease duration of 7.5 years (median – (3.5; 12.5)), with the onset of the disease at 24 years (median –(19; 30)), with V anatomical type - (72.5%), which had vascular stage (77.5%), III grade (≥2) of vascular complications (37.5%), severe exacerbation (65%), with pronounced activity (92.5%) according to the EULAR criteria, high laboratory activity (accelerated ESR in 75% and increased hsCRP - in 65.71% of patients). The lesion of the common carotid (85%) and subclavian arteries (85%) prevailed, the renal arteries were the second most frequently (62.5%) affected vessels, with a predominance of bilateral stenosis (96.1%). During the 5.5 year- follow-up course, a statistically significant partial remission (according to the BVAS index) was achieved in only 12.5% of patients, while frequency of mild and severe exacerbations of the disease remained at the same level (p> 0.05). However, according to the EULAR criteria, there was a statistically significant decrease in the disease activity (from 92.5% to 65% cases) and an increase in the frequency of remission (from 2.5% to 27.5% cases), with the exception of episodes of relapses: major (12.5%) and minor ones (45%).},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients
    AU  - Koilubaeva Gulazyk Malikovna
    AU  - Bolotbekova Altynai Maratovna
    AU  - Egorova Olga Nikolaevna
    AU  - Tarasova Galina Michailovna
    AU  - Sarybaev Akbai Shogaipovich
    AU  - Chukubaev Marat Abdyganovich
    AU  - Turdukulov Zamir Ergeshevich
    AU  - Usupbaeva Dinara Abulmeizovna
    AU  - Turusbekova Aijan Kemelovna
    Y1  - 2022/02/16
    PY  - 2022
    N1  - https://doi.org/10.11648/j.sjcm.20221101.13
    DO  - 10.11648/j.sjcm.20221101.13
    T2  - Science Journal of Clinical Medicine
    JF  - Science Journal of Clinical Medicine
    JO  - Science Journal of Clinical Medicine
    SP  - 14
    EP  - 24
    PB  - Science Publishing Group
    SN  - 2327-2732
    UR  - https://doi.org/10.11648/j.sjcm.20221101.13
    AB  - Monitoring of clinical and laboratory Takayasu's arteritis (TAK) activity was carried out in 40 patients. Most of them were female patients (92.5%), of Kyrgyz nationality (97.5%), of young age (median - 32 years [24; 44]), with a disease duration of 7.5 years (median – (3.5; 12.5)), with the onset of the disease at 24 years (median –(19; 30)), with V anatomical type - (72.5%), which had vascular stage (77.5%), III grade (≥2) of vascular complications (37.5%), severe exacerbation (65%), with pronounced activity (92.5%) according to the EULAR criteria, high laboratory activity (accelerated ESR in 75% and increased hsCRP - in 65.71% of patients). The lesion of the common carotid (85%) and subclavian arteries (85%) prevailed, the renal arteries were the second most frequently (62.5%) affected vessels, with a predominance of bilateral stenosis (96.1%). During the 5.5 year- follow-up course, a statistically significant partial remission (according to the BVAS index) was achieved in only 12.5% of patients, while frequency of mild and severe exacerbations of the disease remained at the same level (p> 0.05). However, according to the EULAR criteria, there was a statistically significant decrease in the disease activity (from 92.5% to 65% cases) and an increase in the frequency of remission (from 2.5% to 27.5% cases), with the exception of episodes of relapses: major (12.5%) and minor ones (45%).
    VL  - 11
    IS  - 1
    ER  - 

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Author Information
  • National Centre of Cardiology and Internal Medicine (NCIIM), Bishkek, the Kyrgyz Republic

  • National Centre of Cardiology and Internal Medicine (NCIIM), Bishkek, the Kyrgyz Republic

  • Research Institute of Rheumatology Named After V. A. Nasonova Federal State Budgetary Institution, Moscow, the Russian Federation

  • Research Institute of Rheumatology Named After V. A. Nasonova Federal State Budgetary Institution, Moscow, the Russian Federation

  • National Centre of Cardiology and Internal Medicine (NCIIM), Bishkek, the Kyrgyz Republic

  • National Centre of Cardiology and Internal Medicine (NCIIM), Bishkek, the Kyrgyz Republic

  • National Centre of Cardiology and Internal Medicine (NCIIM), Bishkek, the Kyrgyz Republic

  • National Centre of Cardiology and Internal Medicine (NCIIM), Bishkek, the Kyrgyz Republic

  • National Centre of Cardiology and Internal Medicine (NCIIM), Bishkek, the Kyrgyz Republic

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